Actor and director Harold Ramis, best known for the films Ghostbusters and Groundhog Day, has died aged 69.
He died of autoimmune inflammatory vasculitis, a rare disease that involves swelling of the blood vessels, his agent told the BBC.
The star found fame as bespectacled ghost-hunter Egon Spengler in the Ghostbusters franchise in 1984.
But he was also a talented writer and director, whose credits included Caddyshack and Animal House.
"His creativity, compassion, intelligence, humour and spirit will be missed by all who knew and loved him," said his family in a statement.
The star had reportedly been quiet about his illness, which dated back to 2010.
'The real deal'
But several friends are said to have visited him recently, including Bill Murray from whom he had been estranged for years, the Chicago Tribune said.
Ramis' death prompted an outpouring of tributes on Twitter.
Billy Crystal, who starred in the director's mobster comedies Analyze This and Analyze That, wrote: "Sad to hear my friend Harold Ramis passed away.
"A brilliant, funny actor and director. A wonderful husband and dad. Big loss to us all."
Iron Man director Jon Favreau added: "No, no, not Harold Ramis. Worked for him years ago. He was the real deal. Growing up, his work changed my life. He will be missed."
'Straight man'
Family Guy creator Seth McFarlane wrote: "Harold Ramis was a brilliant, shining example for every comedy writer hoping to achieve excellence [in] the field."
Born in Chicago to convenience store owners Ruth and Nathan, Ramis studied at Washington University in St Louis and, on graduation, briefly worked in a psychiatric ward.
He started his career as a writer by penning arts stories for his local newspaper and editing Playboy magazine's "party jokes" section.
After leaving the magazine, he joined Chicago's renowned Second City improvised comedy troupe but said he realised his limitations as a performer after encountering John Belushi.
"When I saw how far he was willing to go to get a laugh or to make a point on stage, the language he would use, how physical he was, throwing himself literally off the stage, taking big falls, strangling other actors, I thought: 'I'm never going to be this big.'"
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